Rare Disease Day is an observance held on the last day of February to raise awareness about diseases that most people will not know of, as well as to improve access to treatment.  I am very honored to donate my 5×1000 each year to the Mario Negri and the Clinical Research Centre for Rare Diseases “Aldo e Cele Daccò” in Ranica (BG) has been actively working in the field of rare diseases documentation and research since 1992.